To further the wishes of those who dedicated their bodies to medical education, in 2000 the department of Anatomy of the Tzu Chi University proposed to the Dharma master Cheng Yen of Tzu-Chi to pioneer a clinical skill training program based on un-embalmed bodies. With the support from the Dharma master, professor Guo-Fang Tseng, the current director of the Medical Simulation Center, and Dr. Yueh-Jan Wang, head of the anatomy department planned from scratch to establish an interaction-based and silent mentor-based clinical skill training program. On May 26-29, 2002, together with surgeons from the Hua-lien Tzu-Chi Medical Center, the team formulated and conducted the first basic clinical skill and surgery training program to the second class of the medical students of the Tzu-Chi University a week before graduating. This marked the beginning of a new era of the medical education in Taiwan.

　Following the success of the first simulation course conducted in the Gross Anatomy Lab, the university configured a surgery simulation room with 8 operation tables and specially designed quick freezing facility under the assistance of the Tzu-Chi Foundation and its charity, medicine, education and culture missions and inaugurated in September 15, 2003. With the advances of the operations and to accommodate more disciplines of training, in particular minimally invasive surgery and endoscopy, the training facility underwent renovation and the new Medical Simulation Center started its operation on September 2008.